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This book is a compilation of chapters describing evidence- based developmentally focused programs to prevent subtance abuse. All programs were tested as part of the Center for Substance Abuse Prevention Predictors Variable Initiative, a collaborative, multi-site project in which I was involved. It also represents my strong interest in Prevention Science, one of my career objectives to translate research to practice, and my committment to enhancing prevention practice in communities by disseminating empirically-validated programs.